S-values in target and adjacent cells with idealized spherical models using monoenergetic electron sources
Abstract
Auger electron (AE) emitters are continuously being studied due to AEs having low energies that correspond to electron ranges in the micron scale while also being produced in cascade for each decay. In vitro studies have been limited only to the efficacy of AE-emitters in terms of cell death and vector delivery mechanisms, while computational methods have mainly focused on measuring dose in single-cell models for prominent radionuclides. This study aimed to investigate energy deposition in a two-cell cluster with the nucleus and membrane serving as possible regions of activity localization. The findings show that the membrane can receive a high dose while contributing only a small amount to the total cellular volume. Additionally, cross-dose to an adjacent cell does not vary significantly between the two source regions. Ratios between the self-dose and cross dose have been found to peak at certain energies for the specific cell geometry used in this study.
Downloads
Published
Issue
Section
License
By submitting their manuscript to the Samahang Pisika ng Pilipinas (SPP) for consideration, the Authors warrant that their work is original, does not infringe on existing copyrights, and is not under active consideration for publication elsewhere.
Upon acceptance of their manuscript, the Authors further agree to grant SPP the non-exclusive, worldwide, and royalty-free rights to record, edit, copy, reproduce, publish, distribute, and use all or part of the manuscript for any purpose, in any media now existing or developed in the future, either individually or as part of a collection.
All other associated economic and moral rights as granted by the Intellectual Property Code of the Philippines are maintained by the Authors.
