Gold nanoparticles for medical imaging and x-ray drug delivery system

Abstract

This research aims to develop gold nanoparticles drug-delivery system (DDS) for non-invasive imaging for future dynamic tracking radiation therapy and X-ray DDS. To achieve this, the uptake of gold nanoparticles into pancreas cancer cells was quantified. Gold nanoparticles intracellular uptake was investigated using pancreas cancer human cells PK-1 , PK-45H and Panc-1. Cellular uptake using different gold nanoparticles sizes was analyzed using Atomic Absorption Spectrometry (AAS). It was found that 20 nm gold nanoparticles uptake is higher compared to other gold nanoparticles sizes. The dependence on incubation time and concentration was also investigated. Accumulation of gold nanoparticles can be increased further thru longer incubation and higher concentration. From these results, the optimum condition for the uptake of gold nanoparticles by pancreas cancer cells was determined. Initial study using modified gold nanoparticles in-vivo was also conducted. The findings of this study will help in the design and optimization of the nanoparticles uptake for therapeutic and diagnostic applications of X-ray Drug Delivery System.