Pinpoint x-ray cancer therapy system and DNA damage/repair analysis system of DNA damage

Authors

Mitsuru Uesaka Nuclear Professional School/Engineering and Management Department, University of Tokyo
Kazuyuki Demachi Nuclear Professional School/Engineering and Management Department, University of Tokyo
Takeo Fujiwara Nuclear Professional School/Engineering and Management Department, University of Tokyo
Katsuhiro Dobashi Nuclear Professional School/Engineering and Management Department, University of Tokyo
Hiroko Fujisawa Nuclear Professional School/Engineering and Management Department, University of Tokyo
Ritu Bhusal Chhatkuli Nuclear Professional School/Engineering and Management Department, University of Tokyo
Akihisa Tsuda Nuclear Professional School/Engineering and Management Department, University of Tokyo
Sodai Tanaka Nuclear Professional School/Engineering and Management Department, University of Tokyo
Yasushi Matsumura Nuclear Professional School/Engineering and Management Department, University of Tokyo
Shohei Otsuki Nuclear Professional School/Engineering and Management Department, University of Tokyo
Jyoichi Kusano Accuthera Co.
Masashi Yamamoto Accuthera Co.
Naoki Nakamura Accuthera Co.
Eiji Tanabe Accuthera Co.
Kazuyoshi Koyama High Energy Accelerator Development Organization
Masaki Yoshida High Energy Accelerator Development Organization
Ryuji Fujimori National Institute of Radiological Sciences
Akira Yasui Institute of Development, Aging and Cancer, Tohoku University

Abstract

We are developing compact electron linear accelerators (hereafter linac) with high RF (Radio Frequency) frequency (9.3 GHz, wavelength 32.3 mm) of X-band and applying to medicine and non-destructive testing. Especially, potable 950 keV and 3.95 MeV linac X-ray sources have been developed for on-site transmission testing at several industrial plants and civil infrastructures including bridges. 6 MeV linac have been made for pinpoint X-ray dynamic tracking cancer therapy. The length of the accelerating tube is ~600 mm. The electron beam size at the X-ray target is less than 1 mm and X-ray spot size at the cancer is less than 3 mm. Several hardware and software are under construction for dynamic tracking therapy for moving lung cancer. Moreover, as an ultimate compact linac, we are designing and manufacturing a laser dielectric linac of ~1 MeV with Yr fiber laser (283 THz, wavelength 1.06 µm). Since the wavelength is 1.06 µm, the length of one accelerating strcture is tens µm and the electron beam size is in sub- micro meter. Since the sizes of cell and nuclear are about 10 and 1 µm, respectively, we plan to use this "On-chip" linac for radiation-induced DNA damage/repair analysis. We are thinking a system where DNA in a nucleus of cell is hit by ~1 µm electron or X-ray beam and observe its repair by proteins and enzymes in live cells in-situ. We try to apply this device to analyses of low dose radiation biological effect, especially Fukushima residents, and radiation sensitivity. Finally, we try to combine the pinpoint radiation therapy and radiation sensitivity analysis toward "Tailor-made Radiation Therapy."

About the Speaker

Mitsuru Uesaka, Nuclear Professional School/Engineering and Management Department, University of Tokyo

Mitsuku Uesaka became a Dr. of Engineering in 1985 after he graduated from The University of Tokyo (School of Engineering, Nuclear Engineering Department). His fields of interest include Quantum Beam Engineering, Advanced Compact Accelerator Development, Medical Physics, and Condition-based Maintenance Technology. He is currently a Professor at the Nuclear Professional School, School of Engineering, University of Tokyo.

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Issue

2013: Proceedings of the 31st Samahang Pisika ng Pilipinas Physics Congress

Article ID

SPP2013-PS-6

Section

Invited Presentations

Published

2013-10-23

How to Cite

[1]

M Uesaka, K Demachi, T Fujiwara, K Dobashi, H Fujisawa, RB Chhatkuli, A Tsuda, S Tanaka, Y Matsumura, S Otsuki, J Kusano, M Yamamoto, N Nakamura, E Tanabe, K Koyama, M Yoshida, R Fujimori, and A Yasui, Pinpoint x-ray cancer therapy system and DNA damage/repair analysis system of DNA damage, Proceedings of the Samahang Pisika ng Pilipinas 31, SPP2013-PS-6 (2013). URL: https://proceedings.spp-online.org/article/view/SPP2013-PS-6.