Defects in Neuronal Responses using Hodgkin-Huxley Model

Authors

  • James Christopher S. Pang National Institute of Physics, University of the Philippines Diliman
  • Johnrob Y. Bantang National Institute of Physics, University of the Philippines Diliman

Abstract

We study the parameter sensitivity of the Hodgkin-Huxley model as it responds to a constant input current density at normal levels (10μ A/cm2). Our statistical analyses of firing frequency and refractory period reveal that the production of action potentials is sensitive to at least 12% deviation of the parameters relating the neuronal membrane conductance for sodium and potassium ions, as well as to its membrane’s reversal potential for sodium ions. Interestingly, neurons appear to be insensitive to defects that affect potassium ion reversal potential. Our results therefore suggest that sodium ion related defects (either physical orgenetic) are at least twice more likely to cause defects in neuronal response.

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Issue

Article ID

SPP2013-PA-3

Section

Poster Session PA

Published

2013-10-23

How to Cite

[1]
JCS Pang and JY Bantang, Defects in Neuronal Responses using Hodgkin-Huxley Model, Proceedings of the Samahang Pisika ng Pilipinas 31, SPP2013-PA-3 (2013). URL: https://proceedings.spp-online.org/article/view/SPP2013-PA-3.