Defects in Neuronal Responses using Hodgkin-Huxley Model

Abstract

We study the parameter sensitivity of the Hodgkin-Huxley model as it responds to a constant input current density at normal levels (10μ A/cm2). Our statistical analyses of firing frequency and refractory period reveal that the production of action potentials is sensitive to at least 12% deviation of the parameters relating the neuronal membrane conductance for sodium and potassium ions, as well as to its membrane’s reversal potential for sodium ions. Interestingly, neurons appear to be insensitive to defects that affect potassium ion reversal potential. Our results therefore suggest that sodium ion related defects (either physical orgenetic) are at least twice more likely to cause defects in neuronal response.