Estimation of DNA damage yields in BNCT by Monte Carlo track structure simulation
Boron neutron capture therapy (BNCT) is now received renewed interested therapy. However, biological experiments or clinical data for BNCT are much less than for other radiation therapies. It is important to evaluate the biological effectiveness of BNCT by understanding of initial process. In this study, the yields of chemical species after water radiolysis and DNA stand breaks in boron neutron capture reaction (BNCR) using Monte Carlo track structure method. As the results, the overlapping effect for the and can be negligible in chemical process. The yields of SSB and DSB are within the reasonable range by comparison with previous works of both experiment and simulation. However, there is significant difference between the simulation results and the available experimental data for BNCR.