Estimation of DNA damage yields in BNCT by Monte Carlo track structure simulation

Authors

Masaaki Kaburagi ⋅ JP Nuclear Engineering and Management Department Graduate School of Engineering, University of Tokyo
Ritsuko Watanabe ⋅ JP Japan Atomic Energy Agency
Akinari Yokoya ⋅ JP Japan Atomic Energy Agency
Mitsuru Uesaka ⋅ JP Nuclear Professional school of Engineering, University of Tokyo

Abstract

Boron neutron capture therapy (BNCT) is now received renewed interested therapy. However, biological experiments or clinical data for BNCT are much less than for other radiation therapies. It is important to evaluate the biological effectiveness of BNCT by understanding of initial process. In this study, the yields of chemical species after water radiolysis and DNA stand breaks in boron neutron capture reaction (BNCR) using Monte Carlo track structure method. As the results, the overlapping effect for the and can be negligible in chemical process. The yields of SSB and DSB are within the reasonable range by comparison with previous works of both experiment and simulation. However, there is significant difference between the simulation results and the available experimental data for BNCR.

Downloads

Issue

2012: Proceedings of the 30th Samahang Pisika ng Pilipinas Physics Congress

Article ID

SPP2012-4C-2

Section

Computational Physics and Signal Processing

Published

2012-10-22

How to Cite

[1]

M Kaburagi, R Watanabe, A Yokoya, and M Uesaka, Estimation of DNA damage yields in BNCT by Monte Carlo track structure simulation, Proceedings of the Samahang Pisika ng Pilipinas 30, SPP2012-4C-2 (2012). URL: https://proceedings.spp-online.org/article/view/SPP2012-4C-2.