Microfluidics and single cell immunology for immune system characterization, diagnostics, and drug discovery

Authors

  • Jonathan C. Briones ⋅ JP Institute for Open and Transdisciplinary Research Initiatives, Osaka University

Abstract

Over the past years, microfluidics technology has grown from simple microsystem devices to more complex designs. It has become a popular choice for micro-total analysis systems by providing high precision liquid manipulation that conventional bench-top approaches can't do. This has led to its widespread application in single-cell analysis of immune cells for signaling molecules measurement, novel functional immune cell subsets identiļ¬cation, and comprehension of cellular communication/signaling pathways with the aim of developing new therapies, point-of-care diagnostics, and new drugs to manipulate and modulate the immune system.
The development of microfluidic platforms for single-cell analysis allowed us to account for heterogenous behavior of immune cells, which are often masked when conventional bulk methods are used. Here, we present some of our work on profiling single cells based on cell surface receptors, T-cell and antigen presenting cell (APC) interaction and activation, and granzyme B and cytokine production for cancer immunotherapy response prediction and treatment personalization.

About the Speaker

Jonathan C. Briones, Institute for Open and Transdisciplinary Research Initiatives, Osaka University

Jonathan Briones received his B.S.E in Physics and Technology in 2004 from Philippine Normal University, Manila, M.S. in Physics in 2015 from De La Salle University, Manila, and obtained his Ph.D. in Engineering in 2021 from Osaka University. He worked as a Specially Appointed Researcher at the Institute of Scientific and Industrial Research in 2021 and is currently working at the Institute for Open and Transdisciplinary Research Initiatives in Osaka University. His research focuses on microfluidics engineering for bio sensing applications. His current work is on single-cell profiling and analysis of immunological cells with applications in cancer immunotherapy.

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Issue

Article ID

SPP-2022-INV-2F-02

Section

Invited Presentations

Published

2022-09-11

How to Cite

[1]
JC Briones, Microfluidics and single cell immunology for immune system characterization, diagnostics, and drug discovery, Proceedings of the Samahang Pisika ng Pilipinas 40, SPP-2022-INV-2F-02 (2022). URL: https://proceedings.spp-online.org/article/view/SPP-2022-INV-2F-02.