Raman spectroscopy of vulvar tissue: normal and lichen sclerosus

Authors

Marie Josephine M. De Luna Department of Physical Sciences and Mathematics, University of the Philippines Manila
Tom C. Bakker Schut Center for Optical Diagnostics and Therapy, Department of Dermatology, Erasmus University Medical Center
Gerwin J. Puppels Center for Optical Diagnostics and Therapy, Department of Dermatology, Erasmus University Medical Center
Senada Koljenovic Department of Pathology, Erasmus University Medical Center
Bas W. D. de Jong Department of Pathology, Erasmus University Medical Center
Patricia C. Ewing Department of Pathology, Erasmus University Medical Center
Linda A. M. Santegoets Department of Obstetrics and Gynecology, Erasmus University Medical Center
Leen J. Blok Department of Obstetrics and Gynecology, Erasmus University Medical Center

Abstract

Normal and lichen sclerosus (LS) vulvar tissues were measured in vitro using Raman spectroscopy. Cluster averages and false-color Raman maps were generated using principal component analysis (PCA) and k-means cluster analysis. The Raman spectra show consistent differences between lichen sclerosus (LS) lesions and normal vulvar epithelium. These differences are attributed to biochemical changes in the tissue, which could be possible indicators of lichen sclerosus.

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Issue

2009: Proceedings of the 27th Samahang Pisika ng Pilipinas Physics Congress

Article ID

SPP-2009-7C-04

Section

Instrumentation and Life Sciences

Published

2009-10-28

How to Cite

[1]

MJM De Luna, TC Bakker Schut, GJ Puppels, S Koljenovic, BWD de Jong, PC Ewing, LAM Santegoets, and LJ Blok, Raman spectroscopy of vulvar tissue: normal and lichen sclerosus, Proceedings of the Samahang Pisika ng Pilipinas 27, SPP-2009-7C-04 (2009). URL: https://proceedings.spp-online.org/article/view/SPP-2009-7C-04.