Morphological structures of polycaprolactone nanofibers prepared by electrospinning
Abstract
This study aims to determine the optimum operating parameters in electrospinning polycaprolactone to be used as a scaffold for tissue engineering applications. Polycaprolactone (PCL) is a widely used biocompatible and biodegradable polymer. The polycaprolactone was dissolved in dichloromethane and was electrospun using a 20kV power supply. The needle size used were 25G and 29G needles. For the feed-to-collector distance, the solution was tested at 10 cm, 18 cm, and 25 cm. The morphology of the nanofibers produced were characterized using scanning electron microscopy (SEM). The trend of the nanofibers was evaluated with respect to fiber diameter, presence of beading and consistency of the fibers. Based from the results of the experiment, the effective parameters in producing polycaprolactone nanofiber of good morphological properties are high viscous solutions, 29G needle size and 18 cm tip-to-collector distance.