Polarized light microscopy study on the effect of chlorpromazine concentration on membrane bilayer formation

Authors

Maria Teresa Palamine National Institute of Physics, University of the Philippines Diliman
Melvin Estonactoc National Institute of Physics, University of the Philippines Diliman
Serafin Delica National Institute of Physics, University of the Philippines Diliman

Abstract

Chlorpromazine (CPZ), a cationic, amphiphilic phenothiazine derivative widely used as an antipsychotic drug has been extensively studied for its various effects on biological and artificial model membranes. We report here our study on how CPZ concentration affects the bilayer formation of a lecithin-water lyotropic system. The lecithin-water (control) system exhibited textures characteristic of the lamellar liquid crystalline phase. This phase was found to persist in systems with CPZ concentration equal to or less than 20% by weight of that of the control system, as evidenced by the textures formed by the systems under the polarizing microscope. However, for the system containing 25% CPZ, no textures were seen, suggesting that the bilayer configuration of the lecithin-water system is already destroyed.

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Issue

2002: Proceedings of the 20th Samahang Pisika ng Pilipinas Physics Congress

Article ID

SPP-2002-PP-13

Section

Condensed Matter and Plasma Physics

Published

2002-10-23

How to Cite

[1]

MT Palamine, M Estonactoc, and S Delica, Polarized light microscopy study on the effect of chlorpromazine concentration on membrane bilayer formation, Proceedings of the Samahang Pisika ng Pilipinas 20, SPP-2002-PP-13 (2002). URL: https://proceedings.spp-online.org/article/view/SPP-2002-PP-13.